Assessment of Benefits and Risks
Background and objectives
The remit of the task force is to review how novel foods, novel food ingredients and new processing techniques should be evaluated scientifically from safety and nutritional viewpoints. Due to its work on food biotechnology, the task force gained substantial knowledge in assessing the safety and nutrition of novel foods. This knowledge was broadened in recent years due to various networking activities and the project on the safety assessment of engineered nanomaterials (ENMs) in food. As this project is drawing to a close, the task force is considering a new activity to look at the methodology on how risk assessment for novel foods could be done taking into account developments in new technologies.
Impact
Previously, the task force focused its work on food biotechnology and produced numerous publications on this topic before extending its remit to the safety assessment of novel foods in general. The publications on post-market monitoring and the history of safe use are widely cited and presented at international conferences.
Activities
New Technologies for the Safety Assessment of Novel Foods
Innovation in the food industry to define and discover new and novel foods and ingredients uses modern techniques, state of the art analytics, and evaluation methods. The trend is toward “animal free” sources, sustainable development, and meeting demands for appreciating ethical aspects of the food chain. Regulations in Europe have mandated that cosmetics and their ingredients shall not be tested in animals. It is to recognise that efforts are also being made in other major industries to apply the so called “3Rs Principles”, which means to reduce the number of animals used for safety testing, refine existing testing methods, and replace animal testing as soon as possible. This new horizon is already affecting the food industry.
In response to the overall support for implementation of the 3R’s (Refinement, Reduction, and Replacement) and regulatory prohibition of animal testing in some sectors, world-wide efforts are in progress to find new methods and approaches to test for hazards and support safety with using as few animals as possible. These new approaches are further driven by the recognition that current toxicological methods should be more predictive for human safety.
The outcomes of this activity will aim to:
- Review the applicability of new technologies for generating safety assessment data and its efficacy compared with existing methods (eg ‘omics’, informatics) and for integrating new types of data (e.g. systems approaches) for safety (risk-based) and nutritional assessment;
- Understand the potential that other new and emerging technologies (e.g. tissue engineering, micro-RNA, stem cells) may play in (risk) assessments in the future.
Approaches to the Safety Assessment of Nanomaterials in Foods
This expert group produced a manuscript on the scientific risk assessment of nanomaterials that was presented and discussed at a workshop in Cascais (13-15 April 2011), Portugal. Successively, the final version of the manuscript was submitted and accepted in Food and Chemical Toxicology as: ‘Engineered nanomaterials (ENMs) in food: guidance for their safety assessment’. This paper consists of the following main chapters: the fate of nanomaterials in the body, a strategy for safety assessment, and a tiered approach for use in the safety assessment of ENMs.
The approach and framework, described in the paper, allows for the safety assessment of ENMs for use in foods in a stepwise, systematic, yet flexible manner, proportionate to their physicochemical characteristics and hence potential for toxicological concern. The safety testing strategy is considered applicable to variations in ENM size within the nanoscale and new generations of ENM.
Dr. Susan Wijnhoven presented the work of this expert group at Eurotox 2011.
Workshop on the Safety Assessment of Nanomaterials in Foods
The work of the expert group was presented to a broader audience at a workshop, which took place on 13 – 15 April 2011 in Cascais, Portugal. This 3-day workshop provided a good platform to discuss and review the draft guidance document with experts from academia and industry, national authorities and representatives from the European Commission and the European Food Safety Authority.
The
workshop consisted of plenary sessions and discussions in working groups focusing on the following topics:
- Selection criteria to identify nanomaterials from a decision-tree;
- Tiered approach for hazard identification and characterisation;
- Methodology for risk assessment;
- Applications/case studies.
The main outcome of the workshop was that the presented approach was confirmed as appropriate. A workshop summary report will be published in the ILSI Europe Report Series.
Task Force Collaborators
Members - 2012
Dr. Paul Hepburn - Chair - |
Unilever |
UK |
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Dr. Neil Buck |
DSM |
CH |
Prof. Andrew Cockburn* |
University of Newcastle |
UK |
Dr. Anne Constable |
Nestlé |
UK |
Dr. Agnès Davi |
Danone |
FR |
Dr. Suzanne De Cort |
Coca-Cola Europe |
BE |
| Ms. Emmanuelle Dominik |
Firmenich |
CH |
Dr. Bernd Haber |
BASF SE |
DE |
| Dr. Thomas Hatzold |
Kraft Foods Europe |
CH |
Dr. Brett Jeffery |
Mars |
UK |
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Dr. Alessandro Chiodini |
ILSI Europe |
BE |
Ms. Belinda Antonio |
ILSI Europe |
BE |
* Scientific Advisor
Expert Group on the Safety Assessment of Nanomaterials
Prof. Andrew Cockburn - Chair - |
University of Newcastle |
UK |
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Dr. Roberta Bradford |
Unilever |
UK |
Dr. Neil Buck |
DSM |
CH |
Dr. David Carlander* |
Nanotechnology Industries Association |
IT |
Dr. Anne Constable |
Nestlé |
UK |
Mr. Gareth Edwards |
Consultant |
UK |
Dr. Bernd Haber |
BASF SE |
DE |
Dr. Paul Hepburn |
Unilever |
UK |
| Mr. John Howlett |
Consultant |
UK |
Dr. Frans Kampers |
Wageningen University |
NL |
Prof. Marek Radomski |
Trinity College Dublin |
IE |
Dr. Hermann Stamm |
European Commission – Joint Research Centre |
IT |
Dr. Susan Wijnhoven |
National Institute of Public Health and Environment (RIVM) |
NL |
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Dr. Alessandro Chiodini |
ILSI Europe |
BE |
* Observer in the expert group as member of the European Food Safety Authority until Nov. 2011
After completion of its activities and publication of the results, this expert group was disbanded on November 2011.
Publications