Skip Ribbon Commands
Skip to main content

Publication Detail

Application of the Margin of Exposure (MoE) Approach to Substances in Food that are Genotoxic and Carcinogenic
 
A.R. Boobis, Editor. Food and Chemical Toxicology 2010;48(Suppl.1):S1-S111
 
This series of papers presents the work of an expert group established by ILSI Europe to follow up the recommendations of an international conference on ‘‘Risk Assessment of Compounds that are both Genotoxic and Carcinogenic: New Approaches”. Twelve genotoxic and carcinogenic chemicals that can be present in food were selected for calculation of a Margin of Exposure (MOE) between a point of departure on the dose–response for oral carcinogenicity in animal studies and estimates of human dietary exposure.
 
The MOE can be used to support prioritisation of risk management action and, if the MOE is very large, on communication of a low level of human health concern. Depending on the approaches taken in determining the point of departure and the estimation of exposure, it is possible to derive very different values for the MOE. It is therefore essential that the selection of the cancer endpoint and mathematical treatment of the data are clearly described and justified if the results of the MOE approach are to be trusted and of value to risk managers. An outline framework for
calculating an MOE is proposed in order to help to ensure transparency in the results.
 
The following files can be downloaded:
 
 
Case studies:
 
 
*This article is published with the consent of the Author and the Food Standards Agency and retains Crown Copyright. You may re-use this document free of charge in any format for research, private study or internal circulation within an organisation. You must re-use it accurately and not in a misleading context. The material must be acknowledged as Crown Copyright and you must give the title of the source document.
For any other use of this material please apply for a Click-Use PSI Licence (http://www.opsi.gov.uk/click-use/system/online/pLogin.asp) or by writing to:
Office of Public Sector Information
Information Policy Team
Kew
Richmond
Surrey
TW9 4DU
e-mail:
licensing@opsi.gov.uk
 
To order free copies of the supplement: publications@ilsieurope.be.