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Best Practices for the Conduct of Animal Studies to Evaluate Crops Genetically Modified for Output Traits
Other 2007

Task Force #5

The rationale for the current project was to provide a platform for the scientific evaluation of crops containing output traits when fed to animals and to promote international harmonization of methods. In addition, the document is intended to provide direction to: 1) a person interested in assessing the scope of studies that should be considered for the evaluation of of animal performance for a particular trait, or 2) a person who wants to evaluate a particular crop containing a nutrient output trait when targeted to a particular species. This document aims to 1) recommend scientifically sound guidelines for the production, harvest, sampling, and analysis of GM crops containing “output” traits (i.e., enhanced protein or amino acids, lipid or fatty acids, carbohydrates, minerals, vitamins and antioxidants, enzymes, and reduced anti-nutrients); 2) describe the potential advantages of modifying specific output traits in plants; 3) provide a systematic approach to determine what studies should be considered; and 4) provide guidance on the experimental design, conduct, and analysis of poultry, livestock and aquaculture experiments using these crops and their coproducts. The safety of GM crops and the products derived from animals fed GM crops are reviewed elsewhere. This publication should be a valuable reference for animal, poultry, and aquaculture scientists worldwide in academia, industry, and government who desire to conduct bioavailability, performance, processing, and animal-derived food product studies with nutrientenhanced crops and their coproducts.

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