Database of Physiological Parameters for Early Life Stages
The ILSI Research Foundation database of human physiological parameters for early life stages was completed and posted on the ILSI website in 2008. .The database is a reference source of appropriate parameter values for physiologically-based pharmacokinetic (PBPK) or biologically-based dose-response (BBDR) models and subsequent use in risk assessment. The US Environmental Protection Agency (EPA) has now updated and combined the early life stage data with physiological data for later life stages, and the comprehensive Physiological Information Database is freely available for download from the EPA website.
The goal of this project was to generate a readily accessible, authoritative and comprehensive database of key physiological parameters at early life stages in humans. As the use of PBPK models in risk assessments increases, there has been a growing need for data on physiological parameter values (e.g., respiratory ventilation rates and volumes, body weight/surface area ratios, organ volumes and weights). In particular, there is a need for values relevant to early developmental life stages. This database brings together data on early life stage parameters that are scattered in many different publications in the literatures of diverse disciplines and specialties.
The ILSI Research Foundation project on physiological parameters was designed to build on related efforts by other investigators to compile PBPK modeling parameters for mice and rats, now included in the Physiological Information Database. Also, the ILSI Research Foundation project expanded and improved upon earlier efforts to compile human parameter values (Arms and Travis 1988; Davies and Morris 1993; Brown et al. 1997) by including more recent data, as well as information on the variability associated with selected parameters. The structure and data elements in the EPA Physiological Information Database are derived largely from the ILSI Research Foundation database designed by our Early Life Stage Physiological Parameters Working Group.
This project was funded through a cooperative agreement with the EPA Office of Research and Development and a similar arrangement with Health Canada.
Physiological Information Database for PBPK Modeling (redirects to EPA)